Min Medicin 2017 #3 by Medicinsk access - issuu
A Functional Polymorphism In The Hmgcr Promoter Affects
SNPs in HMGCR can influence how well such drugs work; they include: . rs17244841; rs17238540 HMGCR: 3-Hydroxy-3-Methylglutaryl-CoA Reductase: Protein Coding: 47: GC05P075336: 47.16: 2: PRKAA2: Protein Kinase AMP-Activated Catalytic Subunit Alpha 2: Protein Coding: 51: GC01P056645: 6.85: 3: INSIG1: Insulin Induced Gene 1: Protein Coding: 41: GC07P155297: 6.80: 4: PRKAA1: Protein Kinase AMP-Activated Catalytic Subunit Alpha 1: Protein Coding: 49: GC05M040759: 6.78: 5: APOE: … 2014-11-24 Activities of 417bp and 317bp HMGCS1 promoter fragments were 2.5 to 4 fold decreased by ACBP. Concordantly, the levels of HMGCS1-mRNA and -protein were diminished to 60% and 70% in ACBP-expressing HeLa cells, respectively. Additionally, ACBP reduces the promoter activity and the mRNA levels of the cholesterogenic HMG-CoA reductase (HMGCR). 2018-12-03 HMGCR gene variation is associated with multiple lipid/lipoprotein traits, especially with triglyceride. The impact of the genetic variance is modest and differs greatly among ethnicities. Data show that 12 SNPs from CETP, APOAI, ABCB1, CYP7A1, and HMGCR genes to be associated with baseline LDL-C and high-density lipoprotein cholesterol levels and increased risk of CAD. Peroxisomal HMGCR might be coded by a second gene, but is not detected because it is more than 35% different from the ER enzyme.
Gene Snapshot. HMG Coenzyme A reductase (Hmgcr) encodes the rate- controlling enzyme of the mevalonate pathway that produces isoprenoids. It is required 10 Products Gene ID: Human(3156) Summary: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback 20 Nov 2017 The low-density lipoprotein cholesterol (LDLC)-lowering allele of a variant in the HMGCR gene that encodes the targeted enzyme in statin 5 Mar 2021 HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase) is a Protein Coding gene. Diseases associated with HMGCR include Familial Species, TM, AA, Chromosomal Location, Gene Symbol, Gene Name, Reference. Human, 7, 888, 5q13.3, HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase 30 May 2010 Statins are a class of cholesterol lowering drugs that inhibit 3-hydroxy-3- methylglutaryl coenzyme A reductase (HMGCR), the enzyme which 24 Aug 2010 methylglutaryl coenzyme A reductase (HMGCR), is required for the generation genes and pathways in tumor development and progression. 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is the key regulatory enzyme for cholesterol biosynthesis.
PDF In search of causal pathways in diabetes: a study using
We selected as instruments two SNPs (rs17238484 and rs12916 ) in the HMGCR gene on the basis of genetic associations with Here we review experimental evidence suggesting that the peroxisomal activity might be due to a second HMGCR gene in mammals. We then present a Invitrogen Anti-HMGCR Polyclonal, Catalog # PA5-97831. Tested in HMGCR Antibody in Western Blot (WB).
Nr: 4 Oktober 2020 - Region Västerbotten
Gene: Hmgcr - ENSMUSG00000021670 - Mus musculus (mouse) General information. Ensembl ID: ENSMUSG00000021670: Name: Hmgcr: Description Symbol Description Category GIFtS GC id Score; 1: HMGCR: 3-Hydroxy-3-Methylglutaryl-CoA Reductase: Protein Coding: 47: GC05P075336: 47.16: 2: PRKAA2: Protein Kinase AMP-Activated Catalytic Subunit Alpha 2 Searching the mammalian genome databases with the protein sequence of human HMGCR revealed only a single HMGCR gene in all three genomes, i.e., only a single gene with a statistically significant similarity to the catalytic domain of HMGCR (TBLASTN E-score < 0.001). The human gene is localized at 5q13.3-q14.3 and the rodent homologs are found Previous studies in cultured cells (Schumacher et al., 2015) revealed that UBIAD1 also inhibits endoplasmic reticulum (ER)-associated degradation (ERAD) of ubiquitinated HMG CoA reductase (HMGCR), the rate-limiting enzyme of the mevalonate pathway that produces cholesterol and essential nonsterol isoprenoids. HMGCR protein and Hmgcr mRNA levels of DMSO-treated cells were defined as 1. Glyceraldehyde-3-phosphate dehydrogenase ( Gapdh ) was a reference gene.
Aldose reductase - Wikipedia.
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AMPK. STATINER. Figur 1. Statiner påverkar HMGCR i mevalonatvägen och därmed cancercellens lipidmetabolism.
The HMGCR genetic variant might be associated with risks of prostate and breast cancers.
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ARC publications - Aging Research Center
In paper II, we studied the interplay between tumor-specific HMGCR levels, preoperative statin use, and the multi-drug resistance gene (MDR1/ABCB1) in breast MEDICAL AND HEALTH SCIENCES; Breast cancer; Statins; HMGCR; Cyclin D1; p27; Clinical trial; Gene expressionprofiling; cholesterol-lowering medication kologisk blockering av HMGCR med statiner har som bekant visats sänka LDL-kolesterolet med klinisk användning, men eftersom bestämning av dessa gene-.